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I am an animal lover and a devoted cat person. I write helpful articles based on my experiences as a cat mom. Cats' urine contains strong-smelling proteins they use to mark their territory, a scent that is nearly impossible to eliminate. Cleaning it can often wet the crystallized proteins and reactivate the odor. It can be upsetting and very stressful. The best way to get rid of the smell in your home is to prevent the cat from peeing there in the first place. Ignoring the problem or yelling at your cat will not make the problem go away.